Gene: [04q12/PAICS] phosphoribosylaminoimidazole carboxylase (AIR carboxylase; EC:4.1.1.21); phosphoribosylaminoimidazole succinocarboxamide synthetase (SAICAR synthetase; EC:6.3.2.6);

FAG

[1] Brayton-1994 found that PAICS (required for steps 6 (AIR carboxylase) and 7 (SAICAR synthetase) of de novo synthesis of purine nucleotides) and PPAT (catalyzes step 1; GEM:04q12/PPAT) are closely linked and divergently transcribed.
[2] GDB have registered another locus coding multifunctional SAICAR synthetase/AIR carboxylase: GEM:08p23/ADE2C1."

REL

GEM:00.0/PAICSP1; GEM:00.0/PAICSP2.

REF

CLO,LOC "Barton JW &: Genomics, 9, 314-321, 1991
EXP "Brayton KA &: JBC, 269, 5313-5321, 1994
LIN,LOC,EXP "Gavalas A &: Mol Cell Biol, 13, 4784-4792, 1993
LOC "Schild D &: PNAS, 87, 2916-2920, 1990

KEY

nucm

CLA

coding, basic

LOC

04 q12

MIM

MIM: 172439

EZN

ENZYME: 4.1.1.21

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