Gene: [04q2/SNCA] synuclein, alpha (non A4 component of amyloid precursor); Parkinson disease, familial 1 (MIM:601508); [NACP PD1 ]
FUN | The SNCA gene encodes a presynaptic protein provisionally involved in neuronal plasticity." |
CAG | [1] The alpha-synuclein has been suggested to
provide a link between Parkinson disease and Alzheimer disease (GEM:21q211/APP) and possibly other neurodegenerative
diseases (Heintz-1997). [2] About autosomal recessive juvenile form of Parkinson disease see GEM:06q2/PARK2. Another form of Parkinson disease maps to Chr 2p13: GEM:02p13/PARK3." |
FAG | The gene coding for synuclein beta maps to Chr 5q35: GEM:05q35/SNCB. On gamma synuclein see GEM:10q23/SNCG." |
REF | PEP,EVO,LOC "Campion D
&: Genomics, 26, 254-257, 1995 CLO,SEQ,LOC "Chen X &: Genomics, 26, 425-427, 1995 MUT,PAT,CAG "Heintz N, Zoghbi H: Nature Genet, 16, N4, 325-327, 1997 MUT "Kruger R &: Nature Genet, 18, N2, 106-108, 1998 PAT,MUT "Polymeropoulos MH &: Science, 276, 2045-2047, 1997 PAT,LIN,LOC "Polymeropoulos MH &: Science, 274, N5290, 1197-1199, 1996 MUT "Rannala B &: Science, 280, 175A, 1998 PRO,LOC "Shibasaki Y &: CCG, 71, 54-55, 1995 LOC "Spillantini MG &: Genomics, 27, N2, 379-381, 1995 COD,SEQ,PEP,EVO,EXP "Ueda K &: BBRC, 205, 1366-1372, 1994 |
SWI | SWISSPROT: P37840 |
KEY | neu |
CLA | coding, basic |
LOC | 04 q21.3-22 |
MIM | MIM: 163890 |
SYN | NACP PD1 |
