Gene: [04q31/TDO2] tryptophan 2,3-dioxygenase (tryptophan oxygenase);

FUN

Systematic name: L-tryptophan:oxygen 2,3-oxidoreductase. The reaction catalyzed: L-tryptophan + O(2) = L-formylkynurenine."

ASS

According to Comings-1989, the structural and functional alterations in this gene may be the cause of Gilles de la Tourette syndrome (GEM:18q221/GTS)."

REF

PRO,LOC,CYG,FUN,PAT,EVO "Comings &: AJHG, 45, A135, 1989a
PRO,LOC,CYG,FUN,PAT,EVO "Comings &: CCG, 51, (HGM10), 979, 1989b
PRO,COD,LOC "Donlon &: CCG, 51, (HGM10), 992, 1989

SWI

SWISSPROT: P48775

KEY

aac

CLA

coding, basic

LOC

04 q31

MIM

MIM: 191070

EZN

ENZYME: 1.13.11.11

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