Gene: [04q34/CASP3] caspase 3, apoptosis-related cysteine protease; apopain (PARP cleavage protease);

FUN

CASP3 inactivates poly(ADP-ribose) polymerase (GEM:01q4/ADPRT) separating the N-terminal DNA-nick sensor of PARP from its C-terminal catalytic domain by cleavage between asp216 and gly217."

MOP

CASP3 is a heterodimer of alpha (17kD) and beta (12kD) subunits derived from a common proenzyme."

REF

LOC "Bullrich F &: Genomics, 36, N2, 362-365, 1996
CLO,SEQ,EXP "Fernandes-Alnemri T &: JBC, 269, 30761-30764, 1994
LOC,FAG "Nasir J &: Mammal Genome, 8, N1, 56-59, 1997
CLO,SEQ,EXP "Nicholson DW &: Nature, 376, 37-43, 1995
CLO,SEQ,EXP "Tewari M &: Cell, 81, 801-809, 1995
LOC "Tiso N &: BBRC, 225, N3, 983-989, 1996

SWI

SWISSPROT: P42574

KEY

pep

CLA

coding, basic

LOC

04 q34

MIM

MIM: 600636

EZN

ENZYME: 3.4.22.?

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