Gene: [04q34/CASP3] caspase 3, apoptosis-related cysteine protease; apopain (PARP cleavage protease);
FUN | CASP3 inactivates poly(ADP-ribose) polymerase (GEM:01q4/ADPRT) separating the N-terminal DNA-nick sensor of PARP from its C-terminal catalytic domain by cleavage between asp216 and gly217." |
MOP | CASP3 is a heterodimer of alpha (17kD) and beta (12kD) subunits derived from a common proenzyme." |
REF | LOC "Bullrich F &: Genomics, 36, N2, 362-365, 1996 CLO,SEQ,EXP "Fernandes-Alnemri T &: JBC, 269, 30761-30764, 1994 LOC,FAG "Nasir J &: Mammal Genome, 8, N1, 56-59, 1997 CLO,SEQ,EXP "Nicholson DW &: Nature, 376, 37-43, 1995 CLO,SEQ,EXP "Tewari M &: Cell, 81, 801-809, 1995 LOC "Tiso N &: BBRC, 225, N3, 983-989, 1996 |
SWI | SWISSPROT: P42574 |
KEY | pep |
CLA | coding, basic |
LOC | 04 q34 |
MIM | MIM: 600636 |
EZN | ENZYME: 3.4.22.? |
