Gene: [05q11/IL6ST] interleukin 6 signal transducer, gp130 (oncostatin M receptor; antigen CDW130);

COM

Rodriguez-1995 assigned the active IL6ST gene to Chr 5q11 and the nontranscribed IL6ST pseudogene (GEM:17p11/IL6STP) to Chr 17p11."

FUN

gp130 is involved in signal transduction of interleukin 6 (GEM:07p21/IL6), interleukin 11 (GEM:19q13/IL11), leukemia inhibitory factor (GEM:22q12/LIF), oncostatin M (GEM:22q12/OSM), and ciliary neurotrophic factor (GEM:11q12/CNTF)."

PSG

GEM:17p11/IL6STP.

REF

SEQ "Hibi M &: Cell, 63, 1149-1157, 1990
CLO "Kidd VJ &: Somat Cell Mol Genet, 18, 477-483, 1992
CLO,LOC "Rodriguez C &: CCG, 70, 64-67, 1995

SWI

SWISSPROT: P40189

KEY

imm, recp, mem, sign

CLA

coding, basic

LOC

05 q11

MIM

MIM: 600694

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