Gene: [05q23/DTR] diphtheria toxin receptor; heparin-binding epidermal growth factor-like growth factor; diphtheria toxin sensitivity; [DTS HEGFL ]
HIS | The linkage between the DTS locus and chr 2 markers was erroneously determined by Roberts,Ruddle-1980. Later the gene responsible for diphtheria toxin sensitivity was assigned to chr 5 in independent studies of various authors (Creagan-1975a and others). In 1987, its regional location in 5q23 was determined by Hayes-1987 and confirmed by Fen-1993." |
FUN | Higashiyama-1991,1992 showed that DTR is integral membrane protein and identical to heparin-binding epidermal growth factor-like growth factor." |
REF | LOC,CYG "Athwal RS &: J Hered, 76, 329-334,
1985 FUN,EVO,MUT "Chang, Neville: JBC, 253, 6866-6871, 1978 LOC,CYG "Creagan RP &: CCG, 14, 279-281, 1975a LOC,CYG "Creagan RP &: PNAS, 72, 2237-2241, 1975b CLO,SEQ,GEN,LOC "Fen Z &: Biochemistry, 32, 7932-7938, 1993 LOC,CYG "George DL, Francke: Somat Cell Genet, 3, 629-638, 1977 FUN,EVO,MUT "Gupta, Siminovitch: PNAS, 75, 3337-3340, 1978 LOC,CYG "Hayes H &: Chromosoma, 96, 26-32, 1987 CLO,SEQ,STR,EXP,FUN "Higashiyama S &: JBC, 267, 6205-6212, 1992 CLO,SEQ,STR,EXP,FUN "Higashiyama S &: Science, 251, 936-939, 1991 FUN,EVO,MUT "Pappenheimer AM: Annu Rev Biochem, 46, 69-94, 1977 COM,LIN,HIS "Roberts, Ruddle: Exp Cell Res, 127, 47-54, 1980 LOC,CYG "Ruddle FH &: CCG, 16, 31-53, 1976 |
SWI | SWISSPROT: Q99075 |
KEY | mem, recp |
CLA | coding, basic |
LOC | 05 q23 |
MIM | MIM: 126150 |
SYN | DTS HEGFL |
