Gene: [05q31/NPY6R] neuropeptide Y receptor Y6; neuropeptide Y receptor Y1-like; pancreatic polypeptide receptor 2; [PP2 ]
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MOP |
The NPY6R gene encodes a 290-amino acid polypeptide with one striking difference when compared to the mouse ortholog and to other NPY receptors: all human PP2 clones examined contained a single basepair deletion relative to the mouse ortholog, resulting in a truncated protein lacking the seventh transmembrane domain (Gregor-1996)." |
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FUN |
The NPY6R gene product, when expressed, was unable to bind PP, NPY, or PYY, and Gregor et al. suggested that in humans, NPY6R is either functionally inactive or has a PP-independent function (Gregor-1996)." |
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REF |
COD,SEQ,EXP "Gregor P &: JBC, 271, 27776-27781, 1996 CLO,SEQ "Matsumoto M &: JBC, 271, 27217-27220, 1996 CLO,SEQ "Rose PM &: JBC, 272, N6, 3622-3627, 1997 |
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KEY |
neu, horm, sign, recp |
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CLA |
coding, basic |
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LOC |
05 q31 |
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MIM |
MIM: 601770 |
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SYN |
PP2 |
