Gene: [05q35/NPM1] nucleophosmin (nucleolar phosphoprotein B23, numatrin); non-Hodgkin's lymphoma with t(2;5)(p23;q35); myelodysplastic syndrome and acute myeloid leukemia with t(3;5)(q25.1;q35);

FAG

[1] NMP1 fuses to the anaplastic lymphoma kinase (GEM:02p23/ALK) in non-Hodgkin's lymphoma with t(2;5)(p23;q35) chromosomal translocation (Morris-1994).
[2] NMP1 fuses to the myeloid leukemia factor 1 (GEM:03q251/MLF1) in myelodysplastic syndrome and acute myeloid leukemia with t(3;5)(q25.1;q35) chromosomal translocation (Yoneda-Kato-1996)."

PSG

GEM:00.0/NPMP1; GEM:00.0/NPMP2; GEM:00.0/NPMP3; GEM:00.0/NPMP4; GEM:00.0/NPMP5; GEM:00.0/NPMP6; GEM:00.0/NPMP7."

REF

CLO,SEQ,EXP "Chan WY &: Biochemistry, 28, 1033-1039, 1989
CLO,SEQ,EXP "Liu QR &: DNA Cell Biol, 12, 149-156, 1993
LOC,ABR "Morris SW &: Science, 263, 1281-1284, 1994
LOC,ABR "Yoneda-Kato N &: Oncogene, 12, 265-275, 1996

SWI

SWISSPROT: P06748

KEY

onc

CLA

coding, basic

LOC

05 q35

MIM

MIM: 164040

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