Gene: [05q3/HTR4] 5-hydroxytryptamine (serotonin) receptor 4; cardiac 5-HT4 (serotonin 5-HT-4A) receptor;

COM

The human HTR4 gene was cloned from heart and mapped to 5q31-q33 by fluorescence in situ hybridization (Claeysen-1997)."

FUN

The HTR4 protein mediates widespread effects in central and peripheral nervous systems (Eglen-1995). It may be responsible for the serotonin responsiveness of the human atrium (Blondel-1997)."

REF

COD,SEQ,EVO,MOP "Blondel O &: FEBS Lett, 412, 465-474, 1997
LOC "Claeysen S &: CCG, 78, 133-134, 1997
REV,FUN,EXP "Eglen RM &: Trends Pharmacol Sci, 16, 391-398, 1995
CLO,SEQ "Ullmer C &: FEBS Lett, 370, 215-221, 1995

SWI

 SWISSPROT: Q13639

KEY

neu, recp, sign

CLA

coding, basic

LOC

05 q31-33

MIM

 MIM: 602164