Gene: [06p213/H4FM] H4 histone family, member M; [H4/M ]
|
COM |
[1] By fluorescence in situ hybridization,the H4/m gene was mapped to
6p21.3
(Akasaka-1997), within the cluster of histone genes in this region
(Albig-1997).
[2] The H4/m gene was substituted for the 5-prime regulatory elements of BCL6 (GEM:03q27/BCL6) and fused with coding exons 3-9 of BCL6 in the same transcriptional orientation. Since H4 gene expression is tightly coupled to DNA replication, Akasaka-1997 suggested that the translocation causes inappropriate expression of BCL6 during the cell cycle, leading to the development of non-Hodgkin lymphoma." |
|
REF |
LOC,ABR,EXP "Akasaka T &: Cancer Res, 57, 7-12, 1997 GEN,MAP "Albig W, Doenecke D: Hum Genet, 101, N3, 284-294, 1997a |
|
KEY |
chr |
|
CLA |
coding, basic |
|
LOC |
06 p21.3 |
|
MIM |
MIM: 602833 |
|
SYN |
H4/M |
