Gene: [06p/RHAG] Rhesus blood group-associated glycoprotein, 50kD; Rh deficiency syndrome (RH-null hemolytic anemia; MIM:268150); [RH50A ]

COM

By isotopic in situ hybridization Cherif-Zahar-1996 mapped the RHAG gene to 6p21.1-11 (most probably to 6p12)."

SUM

[1] The homozygous state of the minor mutant allele of RHN regulatory gene determines phenotype 'Rh-null' (or Rhesus-negative status). The main clinical features of this phenotype are neonatal anemia (hemolytic anemia with decreased life span of red blood cells, increased fragility of red blood cells, and occurence of fetal hemoglobin). This variant of Rh deficiency syndrome or Rh deficiency hemolytic anemia is denoted 'Rh-mod' (Rh-modified phenotype) and depends exclusively on RHN gene.
[2] Another genetic variant of 'Rh-null' with similar clinical manifestation of anemia is determined by the homozygosity for another rare mutation (so called N.Morton allelomorph) in a locus that is closely linked with the Rhesus complex in chromosome 1p (see a comment in GEM:01p3/RHCE). Thus, the Rh deficiency syndrome is heterogeneous.
[3] Homozygotes with the Rh deficiency anemia (one or another of the two Rh-null variants) occurred very rarely - about 1 per 6 millions, usually in the offspring of consanguinity matings (that is typical for the autosomal recessive inheritance)."

REF

LOC,PAT,MUT "Cherif-Zahar B &: Nature Genet, 12, 168-173, 1996
PHE,PAT,FOG "Chown &: AJHG, 24, 623-637, 1974
LOC,MAP "Miller YE &: AJHG, 41, 1061-1070, 1987
PHE,PAT,FOG "Nash, Shojania: Am J Hematol, 24, 267-275, 1987
CLO,SEQ,LOC "Ridgwell K &: Biochem J, 287, 223-228, 1992
PHE,PAT,FOG "Schmidt, Vos: Vox Sang, 13, 18-20, 1967
PHE,PAT,FOG "Sistonen &: Vox Sang, 48, 174-177, 1985
PHE,PAT,FOG "Vos &: Lancet, 1, 14-15, 1961

SWI

SWISSPROT: Q02094

KEY

mem

CLA

coding, basic

LOC

06 p21.1-11

MIM

MIM: 180297

SYN

RH50A

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