Gene: [06q12/PGM3] phosphoglucomutase 3;

COM

Before 1984, the code was EC:2.7.5.1.

FUN

Systematic name: alpha-D-glucose 1,6-phosphomutase. Catalyzes reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate. This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization. Also, more slowly, catalyses the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate."

TIS

PGM3 is expressed predominantly in red blood cells.

FAG

On the localization of genes coding for phosphoglucomutase isoenzymes, see GEM:01p31/PGM1."

REF

LOC "Jongsma A &: Humangenetik, 20, 195-202, 1973
LOC "Lamm LU &: Tissue Antigens, 2, 205-214, 1972
LOC "Meera Khan &: CCG, 37, (HGM7), 537, 1984

KEY

carb, glyc

CLA

coding, basic

LOC

06 q12

MIM

MIM: 172100

EZN

ENZYME: 5.4.2.2