Gene: [06q21/CCNC] cyclin C (G1/S-specific);
FUN | Cyclin C might activate p34 (or a related kinase). |
MOP | Cyclin C do not contain 'mitotic destruction motif'. However this protein contain PEST sequences, which have been suggested to target proteins for rapid (and constitutive) degradation, near the carboxyl terminus (PEST-FIND score +13)." |
EXP | Cyclin C mRNAs accumulate predominantly early in G1 phase cells. |
EVO | [1] Cyclin C is approximately equally homologous to other
human cyclins (37% similarity to cyclin A) and yeast Clns (43% similarity
to Cln1) in the most conserved region (including most of the cyclin box).
[2] A homolog of cyclin C has been identified in Drosophila (Leopold-1991). Drosophila and human cyclin C are considerably more closelly related to each other (72% identical residues overall) than Drosophila and human cyclin A or cyclin B, which are only 50%-55% identical even within the most conserved cyclin box domain. This degree of conservation across such an evolutionary distance suggests that there are strong constraints on cyclin C structure." |
REF | IDN,FUN,MOP,EXP "Arion
&: Cell, 55, 371-378, 1988 IDN,FUN,MOP,EXP "Booher, Beach: EMBO J, 6, 3441-3447, 1987 IDN,FUN,MOP,EXP "Draetta &: Cell, 56, 829-838, 1989 IDN,FUN,MOP,EXP "Dunphy &: Cell, 54, 423-431, 1988 IDN,FUN,MOP,EXP "Fang, Newport: Cell, 66, 731-742, 1991 IDN,FUN,MOP,EXP "Galaktionov KI, Beach: Cell, 67, 1181-1194, 1991 IDN,FUN,MOP,EXP "Gautier &: Cell, 54, 433-439, 1988 IDN,FUN,MOP,EXP "Giordano &: Cell, 58, 981-990, 1989 IDN,FUN,MOP,EXP "Goebl, Byers: Cell, 54, 739-740, 1988 IDN,FUN,MOP,EXP "Gould, Nurse: Nature, 342, 39-45, 1989 IDN,FUN,MOP,EXP "Inaba T &: Genomics, 13, 565-574, 1992 IDN,FUN,MOP,EXP "Koff A &: Cell, 66, 1217-1228, 1991 IDN,FUN,MOP,EXP "Labbe &: Cell, 57, 253-263, 1989a IDN,FUN,MOP,EXP "Labbe &: EMBO J, 8, 3053-3058, 1989b IDN,FUN,MOP,EXP "Meijer &: EMBO J, 8, 2275-2282, 1989 IDN,FUN,MOP,EXP "Pines J, Hunter: J Cell Biol, 115, 1-17, 1991 IDN,FUN,MOP,EXP "Pines J, Hunter: Nature, 346, 760-763, 1990 PRO,COD,SEQ "Pines J, Hunter: Cell, 58, 833-846, 1989 IDN,FUN,MOP,EXP "Solomon &: Cell, 54, 738-739, 1988 IDN,FUN,MOP,EXP "Tsai LH &: Nature, 353, 174-177, 1991 EVO,EAG "Xiong Y &: Genomics, 13, 575-584, 1992 IDN,FUN,MOP,EXP "Xiong Y &: Cell, 65, 691-699, 1991 EVO,EAG "Xiong Y, Erickbush : EMBO J, 9, 3353-3362, 1990 EVO,EAG "Yoshida MC &: PNAS, 85, 4861-4864, 1988 |
SWI | SWISSPROT: P24863 |
KEY | nucm, onc, repr |
CLA | coding, basic |
LOC | 06 q21 |
MIM | MIM: 123838 |
