Gene: [07p22/CMKRL2] chemokine receptor-like 2 (heptahelix); G protein-coupled receptor 30; IL8-related receptor DRY12; [GPR30 DRY12 ]

COM

[1] Owman-1996 performed PCR of template DNA from human B-cell lymphoblasts using degenerate primers to G protein-coupled receptors. They identified a full-length cDNA encoding a 375-amino acid protein, which they termed CMKRL2. CMKRL2 maps to Chr 7p22 by fluorescence in situ hybridization.
[2] Based upon PCR analysis in somatic hybrid cell lines the GPR30 gene was mapped to Chr 7p22 (Carmeci-1997). The pattern of expression of the gene indicated that the receptor may be involved in physiologic responses specific to hormonally responsive tissues."

TIS

The CMKRL2 is expressed in the Burkitt lymphoma cell lines Raji and Daudi but not in T-cell lymphoma Jurkat cells, T- or B-cell leukemias, chronic myelogenous leukemia, or other cancer cell lines; northern blot analysis of normal tissue showed widespread expression in many tissues including the brain; there was no detectable mRNA in placenta, bone marrow, or peripheral blood leukocytes (Owman-1996)."

REF

CLO,LOC "Carmeci C &: Genomics, 45, N3, 607-617, 1997
CLO,SEQ "Feng Y, Gregor P: BBRC, 231, 651-654, 1997
CLO,SEQ "Kvingedal AM, Smeland EB: FEBS Lett, 407, 59-62, 1997
CLO,SEQ,TIS,LOC "O'Dowd BF &: Genomics, 47, N2, 310-313, 1998
COD,LOC,EXP "Owman C &: BBRC, 228, N2, 285-292, 1996
CLO,SEQ "Takada Y &: BBRC, 240, 737-741, 1997

SWI

SWISSPROT: Q99527

KEY

mem, recp

CLA

coding, basic

LOC

07 p22

MIM

MIM: 601805

SYN

GPR30 DRY12

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