Gene: [07q1123/PTPN12] protein tyrosine phosphatase, non-receptor type 12; protein tyrosine phosphatase G1; colon cancer?;

FUN

[1] Systematic name: protein-tyrosine-phosphate phosphohydrolase.
[2]-Reaction catalyzed: protein tyrosine phosphate + H(2)O = protein tyrosine + orthophosphate."

ASS

In a colorectal carcinoma cell line, DLD-1, Takekawa et al. found 3 aberrant transcripts by RT-PCR. Sequencing in one demonstrated an A-to-G transition at nucleotide 201, predicting a change of codon 61 from lysine to arginine (Takekawa-1994)."

REL

See GEM:20q13/PTPN1.

REF

EAG,MOU,HUM "Charest A &: Genomics, 28, 501-507, 1995
LOC,EXP "Takekawa M &: FEBS Lett, 339, 222-228, 1994
COD,SEQ "Takekawa M &: BBRC, 189, 1223-1230, 1992
COD,SEQ,EXP "Yang Q &: JBC, 268, 6622-6628, 1993

SWI

 SWISSPROT: Q05209

KEY

pep, onc, git

CLA

coding, basic

LOC

07 q11.23

MIM

 MIM: 600079

EZN

 ENZYME: 3.1.3.48