Gene: [07q2/TAC1] tachykinin 1 (substance P, neurokinin 1); tachykinin 2 (substance K, neurokinin A, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma); [NKNA TAC2 ]

EXP

Three different forms of preprotachykinins (alpha, beta, and gamma) arise by alternative splicing. The beta and gamma forms encode both tachykinin 1 and tachykinin 2, while the alpha form contains only the tachykinin 1 (Harmar-1986, Krause-1987)."

FAG

[1] On tachykinin 3 see GEM:12q/TAC3.
[2] On tachykinin receptors see GEM:02^/TACR1, GEM:10q/TACR2, and GEM:00.0/TACR3.
[3] On neuromedin B see GEM:15q/NMB."

REF

PRO,LOC,CYG,MOL,FAG "Bonner TI &: CCG, 46, (HGM9), 584, 1987
CLO,SEQ,EXP "Chiwakata C &: Endocrinology, 128, 2441-2448, 1991
CLO,SEQ,EXP "de Miguel C &: NAR, 16, N4, 1644-1644, 1988
CLO,SEQ,EXP "Harmar AJ &: FEBS Lett, 208, 67-72, 1986
EXP,FUN,RAT "Krause JE &: PNAS, 84, N3, 881-885, 1987
CLO,SEQ,EXP "Theodorsson-Norheim E &: Eur J Biochem, 166, 693-697, 1987

SWI

 SWISSPROT: P20366; TKNG Q00072

KEY

neu, mem

CLA

coding, basic

LOC

07 q2

MIM

 MIM: 162320

SYN

NKNA TAC2