Gene: [07q311/ST7] suppression of tumorigenicity 7 (breast?; ovarian?); ovarian carcinoma?; [TSG7 ]

COM

A distinct tumor suppressor gene involved in primary ovarian carcinomas was suggested by the finding of Zenklusen et al. of allelic loss at 7q31.1 in such carcinomas. In 17 of 19 informative cases (73%), loss of heterozygosity (LOH) was detected in D7S522 at 7q31.1 (Zenklusen-1995a,b)."

REF

CLO,SEQ "Ogata T &: Mol Cell Biol, 13, 6036-6043, 1993
REV,FAG,EXP "Zenklusen JC &: Mol Carcinog, 15, 167-175, 1996
LOC "Zenklusen JC &: Cancer Res, 55, 1347-1350, 1995a
LOC "Zenklusen JC &: Oncogene, 11, N2, 359-363, 1995b
CLO,SEQ,STR "Zenklusen JC &: PNAS, 91, 12155-12158, 1994

KEY

onc

CLA

coding, basic

LOC

07 q31.1

MIM

MIM: 600833

SYN

TSG7

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