Gene: [07q/CACNA2] calcium channel, voltage-dependent, L type, alpha 2/delta subunit; calcium channel, L type, alpha 2 polypeptide; malignant hyperthermia susceptibility 3 (MHS3; MIM:154276); [CACNL2A MHS3 ]

COM

Powers-1994 assigned the CACNA2 gene to Chr 7q21-22 by analysis of a panel of human/rodent somatic cell hybrids (GDB:G00-132-010 points this location) whereas Iles-1994 mapped the CACNL2A gene to Chr 7q11.23-21.1 by fluorescence in situ hybridization [GDB:G00-132-010:LOC='07 q21-22']."

LIN

In MHS families linked to neither Chr 17 (GEM:17q/MHS2) nor Chr 19 (GEM:19q131/RYR1), Iles-1994 found linkage with no recombination to markers flanking the CACNL2A locus on Chr 7."

REF

CLO,LOC,LIN,PAT "Iles DE &: Hum Mol Genet, 3, 969-975, 1994
CLO,LOC "Powers PA &: Genomics, 19, 192-193, 1994

SWI

SWISSPROT: P54289

KEY

sign, ion, neu, mem

CLA

coding, basic

LOC

07 q11.23-21.1

MIM

MIM: 114204

SYN

CACNL2A MHS3

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