Gene: [08p1/POLB] polymerase (DNA directed), beta;
FUN | [1]
Low-molecular (42558 kD, 381 amino acids) N-ethyl maleimide-resistant DNA
polymerase beta probably participates in the reparation of DNA breaks and
hence may be involved into pathogenesis of xeroderma pigmentosum,
ataxia-telangiectasia, and Fanconi's anemia. [2] The reaction catalyzed: N-deoxynucleoside triphosphate = N-pyrophosphate + DNA(N)." |
EVO | Of 4750 amino acid sequences (data bank PIR), POLB exhibits a significant homology only with terminal deoxynucleotidyl exotransferase (GEM:10q2/DNTT): there are 24% identical amino acid residues and 21% conservative amino acid changes. A duplication of an ancestral gene with consequent divergence of POLB and DNTT about 250 Myr ago (before the wide spreading of birds an mammals) is supposed." |
FAG | The gene coding for alpha form of DNA-dependent DNA polymerase is mapped to X chromosome: GEM:0Xp2/POLA." |
PRO | Probes pB19 (740 bp) and pB159 (1215 bp) contain cDNA fragments cloned in the plasmid pUC-8; the stop codon TGA occupies the position 1142-43-44 bp in the cDNA (the total size is 1319 bp)." |
POL | Probe pUC9-10F (438 bp of 5'-terminal EcoRI fragment of rat cDNA) reveals several RFLPs (EcoRI, HindIII, BamHI, SacI, PvuII) within the 5'-vicinity of human POLB." |
REF | MOP,SEQ,EVO "Anderson
&: Gene, 60, 163-173, 1987 LOC,MOL,CYG "Cannizzaro &: CCG, 47, 121-124, 1988 LOC,MOL,CYG "Matsukage A &: Jpn J Cancer Res, 77, 330-333, 1986 LOC,MOL,CYG "McBride OW &: PNAS, 84, N2, 503-507, 1987 CLO,SEQ,EXP "SenGupta DN &: BBRC, 136, 341-347, 1986 REV,MOL,EXP "Wilson S &: BBA, 949, 149-157, 1988 |
SWI | SWISSPROT: P06746 |
KEY | repr, nucm |
CLA | coding, basic |
LOC | 08 p12-11 |
MIM | MIM: 174760 |
EZN | ENZYME: 2.7.7.7 |
