Gene: [08q23/COL14A1] undulin (fibronectin-tenascin-related); collagen, type XIV, alpha 1; [UND ]
|
COM |
[1] The COL14A1/UND gene was mapped to 8q23 by FISH (Schnittger-1995).
[2] Undulin is a noncollagenous extracellular matrix protein (Schuppan-1990). The undulin is identical to collagen XIV (Bauer-1997)." |
|
FUN |
Undulin is a large glycoprotein of the interstitial extracellular matrix. It is restricted to dense and soft connective tissues and is associated with mature collagen fibrils (Schuppan-1990)." |
|
MOP |
[1] The predicted 1,780-amino acid undulin protein contains a putative
signal
peptide followed immediately by a fibronectin type III domain (GEM:02q34/FN1);
a VWF A domain (GEM:12p13/F8VWF); 7
fibronectin type III domains; a
second VWF A domain; and several collagenous and noncollagenous
domains in the C-terminal region (Just-1991; Bauer-1997).
[2] A homotrimeric collagen XIV molecule was extracted from fetal bovine skin and tendon. It has a triple helical disulfide-bonded domain homologous to type IX and type XII collagens (Dublet-1991; see also FAM:COLL/00.0)." |
|
REL |
On tenascin gene see GEM:09q33/HXB. |
|
REF |
COD,SEQ,EVO "Bauer M &: BBA, 1354, N3, 183-188, 1997 MAM,PRO,SEQ,MOP,EVO "Dublet B, van der Rest M: JBC, 266, 6853-6858, 1991 COD,SEQ "Just M &: JBC, 266, 17326-17332, 1991 LOC "Schnittger S &: CCG, 68, 233-234, 1995 EXP,MEB "Schuppan D &: JBC, 265, N15, 8823-8832, 1990 |
|
KEY |
exce |
|
CLA |
coding, basic |
|
LOC |
08 q23 |
|
MIM |
MIM: 120324 |
|
SYN |
UND |
