Gene: [08q242/PSCA] prostate stem cell antigen; prostate cancer?;
|
COM |
The PSCA gene was mapped to chromosome 8q24.2 by FISH (Reiter-1998). |
|
FUN |
PSCA may play a role in prostate cancer progression and may serve as a target for prostate cancer diagnosis and treatment (Reiter-1998)." |
|
COD |
"PSCA encodes a 223-amino acid protein with an amino-terminal signal sequence, a carboxy-terminal GPI-anchoring sequence, and multiple N-glycosylation sites. PSCA is homologous to a group of cell surface proteins that mark the earliest phases of hematopoietic development. PSCA mRNA expression is prostate-specific in normal male tissues (Reiter-1998)." |
|
ASS |
There is moderate to strong PSCA expression in 111 of 126 (88%) prostate cancer specimens examined by in situ analysis, including high-grade prostatic intraepithelial neoplasia and androgen-dependent and androgen-independent tumors." |
|
REF |
COD,SEQ,EXP,LOC "Reiter RE &: PNAS, 95, 1735-1740, 1998 |
|
KEY |
onc, sex |
|
CLA |
coding, basic |
|
LOC |
08 q24.2 |
|
MIM |
MIM: 602470 |
