Gene: [09p13/GGTB2] glycoprotein-4-beta-galactosyltransferase 2 (EC:2.4.1.38); lactose synthase (EC:2.4.1.22); N-acetyllactosamine synthase (EC:2.4.1.90);
COM | Another form of glycoprotein-4-beta-galactosyltransferase was previously suggested, which, by inference, was encoded by an independent locus in Chr 4 (GGTB1). However, it was demonstrated that this gene is most likely to determine one of activators of the enzyme (see GEM:04^/GTA). Thus, only one GGTB gene is currently known in the human genome (that in Chr 9p13)." |
FUN | [1] EC:2.4.1.38; Systematic name:
UDP-galactose:N-acetyl-beta-D-glucosaminyl- glycopeptide
galactosyltransferase. Catalyzes reaction: UDP-galactose +
N-acetyl-beta-D-glucosaminylglycopeptide = UDP +
beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide. [2] In complex with alpha-lactalbumin (GEM:12q13/LALBA), the glycoprotein-4-beta-galactosyltransferase forms a heterodimer protein possessing the lactose synthase (EC:2.4.1.22) enzymatic activity. [3] The reaction EC:2.4.1.90 is catalysed by a component of EC:2.4.1.22, which is identical with EC:2.4.1.38, and by an enzyme from the golgi apparatus of animal tissues." |
REF | PRO,EXP "Appert &: AJHG, 39, A186, 1986 LOC,PRO "Duncan AM &: BBRC, 141, 1185-1188, 1986 LOC,PRO "Shaper NL &: Somat Cell Mol Genet, 12, N6, 633-636, 1986 |
SWI | SWISSPROT: P15291 |
KEY | carb, horm |
CLA | coding, basic |
LOC | 09 p13 |
MIM | MIM: 137060 |
EZN | ENZYME: 2.4.1.38 |
