Gene: [09p13/TPM2] tropomyosin 2 (skeletal muscle beta); [TMSB ]

FUN

The muscle-specific tropomyosin peptides are components of the thin filaments of the sarcomere, the contractile element in muscle, and control contraction in a calcium-dependent manner."

MOP

The skeletal muscle and cytoskeletal beta tropomyosin isoforms are resulted from the alternative splicing of mRNA encoded by the single gene (MacLeod-1985; Widada-1988)."

FAG

Two muscle-specific isoforms of tropomyosin, one alpha and one beta, form an alpha-helical dimer, see details in: GEM 15q221/TPM1."

REF

LOC "Hunt CC &: CCG, 71, 94-95, 1995
PRO,COD,SEQ,EXP,EVO "MacLeod AR &: PNAS, 82, N23, 7835-7839, 1985
PRO,COD,SEQ,EXP,EVO "Widada JS &: NAR, 16, N7, 3109, 1988

SWI

SWISSPROT: P07951; TPM2 P06468

KEY

myo, cysk

CLA

coding, basic

LOC

09 p13

MIM

MIM: 190990

SYN

TMSB

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