Gene: [0Xp221/SMS] spermine synthase;

COM

The spermine synthase gene was found to be located 38 kb telomeric to PEX (GEM:0Xp22/PHEX)."

FUN

Spermine synthase is 1 of 4 enzymes involved in the synthesis of polyamines from arginine and methionine."

GEN

The gene length: 54 kb (or over); exons: 11 (Grief-1997). The open reading frame encodes a 368-amino acid protein with little sequence similarity to proteins from bacterial and mammalian sources catalyzing almost identical reactions (Korhonen-1995)."

FAG

Four enzymes are involved in the synthesis of polyamines from arginine and methionine: spermine synthase, ornithine decarboxylase (GEM:02p25/ODC1, EC:4.1.1.17), S-adenosyl-L-methionine decarboxylase (GEM:06q2/AMD, EC 4.1.1.50), and spermidine synthase (GEM:01p/SRM, EC:2.5.1.16)."

REL

GEM:0Xp221/SAT.

REF

GEN,SEQ,LOC "Grieff M &: Genomics, 44, 227-231, 1997
COD,SEQ "Korhonen V-P &: DNA Cell Biol, 14, 841-847, 1995

SWI

 SWISSPROT: P52788

KEY

aac

CLA

coding, basic

LOC

0X p22.1

MIM

 MIM: 300105

EZN

 ENZYME: 2.5.1.22