Gene: [0Yq11/AZF1] azoospermia factor 1; azoospermia factor (Sertoli-cell-only syndrome);

FAG

Vogt-1996 found microdeletions in 3 different Yq11 subregions that led to spermatogenesis disruption at different phases of the process. They proposed the presence of 3 spermatogenesis loci in Yq11: AZFa (this locus), AZFb (GEM:0Yq11/AZF2) and AZFc (GEM:0Yq11/AZF3) and that each locus is active during a different phase of male germ cell development."

REF

LOC "Andersson &: Hum Genet, 79, 2-7, 1988
LOC "Chandley AC &: J Med Genet, 26, 145-153, 1989
HET,MUT "Kobayashi K &: Hum Mol Genet, 3, 1965-1967, 1994
LOC "Ma K &: Hum Mol Genet, 1, 29-33, 1992
LOC "Tiepolo L, Zuffardi O: Hum Genet, 34, 119-124, 1976
LOC "Vogt PH &: Hum Mol Genet, 5, 933-943, 1996
LOC "Vogt PH &: Hum Genet, 89, 491-496, 1992

KEY

sex

CLA

unknown, basic

LOC

0Y q11

MIM

MIM: 415000

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