Gene: [10q25/MXI1] MAX-interacting protein 1; prostate cancer 1 (MIM:176807); [PRCA1 ]

FUN

The Mxi1 protein functions in a regulatory network with members of the c-Myc family (see GEM:01p32/MYCL1), in which c-Myc activates transcription and stimulates cell proliferation, and Mxi1 negatively regulates these actions. Inactivation of the MXI1 gene could, therefore, inhibit differentiation and enhance proliferation in the presence of normal levels of c-Myc, and thus MXI1 is a potential tumor suppressor gene (Wechsler-1997)."

REF

CLO,SEQ,STR "Albarosa R &: Hum Genet, 95, 709-711, 1995
FOG "Carter BS &: PNAS, 89, N8, 3367-3371, 1992
MUT "Eagle LR &: Nature Genet, 9, 249-255, 1995
LOC "Edelhoff S &: Oncogene, 9, 665-668, 1994
FOG "Edwards A &: Genomics, 12, 241-253, 1992
LIN "Irvine RA &: Cancer Res, 55, 1937-1940, 1995
LOC "Shapiro DN &: Genomics, 23, 282-285, 1994
FUN,EXP "Wechsler DS &: Cancer Res, 57, N21, 4905-4912, 1997
CLO,SEQ,GEN "Wechsler DS &: Genomics, 32, N3, 466-470, 1996
LOC "Wechsler DS &: Genomics, 21, 669-672, 1994
IDN "Zervos AS &: Cell, 72, 223-232, 1993

KEY

trc, onc

CLA

coding, basic

LOC

10 q25

MIM

MIM: 600020

SYN

PRCA1

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