Gene: [10q26/DEC] tumor suppressor DEC (putative); deleted in endometrial carcinoma; endometrial carcinoma;

COM

In 9 of 19 (47%) cases of endometrial carcinoma, Safara et al. demonstrated loss of heterozygosity (LOH) for markers in the 10q23-q26 region. The pattern of deletion suggested a role for a tumor suppressor gene located between markers D10S587 and D10S216, a region spanning 2 cM and important for the development or progression of endometrial carcinoma (Safara-1997)."

REL

GEM:10q2/DMBT1; GEM:16q221/CDH1.

REF

LOC,LIN,ABR "Safara A &: AJHG, 61, A81, 1997

KEY

onc

CLA

unknown, basic

LOC

10 q26

MIM

MIM: 602084