Gene: [10q2/CD39] ATP diphosphohydrolase (vascular); antigen CD39;
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SUM |
Kaczmarek-1996 demonstrated that CD39, a B-cell activation marker previously characterized by Maliszewski-1994, encodes vascular ATP diphosphohydrolase (ATPDase). They isolated the cDNA of human ATPDase/CD39 by RT-PCR using RNA from human umbilical endothelial cells, expressed it in COS7 cells and confirmed that it is expressed on the cell surface, hydrolyzes both ATP and ADP, and inhibits platelet aggregation. CD39 was found to have both immunologic identity to, and functional characteristics of, vascular ATPDase." |
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FUN |
The catabolism of extracellular nucleotides serving as signaling molecules in many extracellular activities is mediated by several types of ectonucleotidases, including the divalent cation-dependent E-type nucleotidases (NTPases). The E-type NTPases include ectoapyrases, such as CD39, which show a significant rate of ADP hydrolysis compared to ATP hydrolysis. NTPases are characterized by the presence of 4 motifs known as apyrase-conserved regions (ACRs)." |
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FAG |
The following genes coding for CD39-like proteins have been found: GEM:09q34/CD39L1; GEM:20q112/CD39L2; GEM:03p213/CD39L3; GEM:14q24/CD39L4." |
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REF |
CLO,COD,EXP,FUN "Kaczmarek E &: JBC, 271, 33116-33122, 1996 COD,LOC "Maliszewski CR &: J Immunol, 153, 3574-3583, 1994 |
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KEY |
imm, mem, card, nucm, sign |
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CLA |
coding, basic |
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LOC |
10 q23.1-24.1 |
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MIM |
MIM: 601752 |
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EZN |
ENZYME: 3.1.?.? |
