Gene: [11p153/LMO1] LIM domain only 1 (rhombotin 1); rhombotin 1 (rhombosine; T cell lymphoma associated breakpoint); T cell acute lymphoblastic leukemia 1 (rhombotin); T cell lymphoma 6 associated breakpoint; [RBTN1 TCL6 ]
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FAG |
Other six LMO sequences have been identified: GEM:11p13/LMO2, GEM:12p13/LMO3, GEM:11p151/LMO4, GEM:12q211/CSRP2(LMO5), GEM:0Xp112/LMO6, GEM:00.0/LMO7." |
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MOP |
Rhombotin 1 (rhombosin) consists of 155 amino acid residues. |
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HET |
Another T cell lymphoma marker identified in the same chromosome is retained yet in the MIM and GEM catalogues (GEM:11p13/TCL2), but was excluded from the HGM ones." |
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MUT |
According to Greenberg-1989, T cell-associated translocation t(22;14)(p15;q11) in human affects the nucleic acid sequence in Chr 11p15, which was demonstrated to be transcribed in a model system on the developing rhombomers of murine cerebral trunk. But the relationship between rhombosine gene defects and T cell lymphoma is not confirmed definitely." |
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HIS |
HGM9: gene symbol TCL6 HGM10: TAL1 HGM10.5: RBTN1 GDB LMO1." |
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REF |
CLO,SEQ,EVO "Boehm T &: Oncogene, 6, 695-703, 1991a CLO,SEQ,EVO "Boehm T &: PNAS, 88, 4367-4371, 1991b CLO,SEQ,EVO "Boehm T &: EMBO J, 9, 857-868, 1990 LOC "Boehm T &: EMBO J, 7, 385-394, 1988a LOC "Boehm T &: Oncogene, 3, 691-695, 1988b LOC,CYG,EXP "Greenberg JM &: CCG, 51, (HGM10), 1008, 1989 LOC,LIN,MOL "Henry I &: CCG, 51, (HGM10), 1013, 1989a LOC,LIN,MOL "Henry I &: Hum Genet, 81, 273-277, 1989b LOC,LIN,MOL "Henry I &: PNAS, 86, 3247-3251, 1989c LOC,LIN,MOL "Henry I &: Ann Genet, 31, 216-220, 1988 LOC,LIN,MOL "Henry I &: CCG, 46, (HGM9), 629, 1987 LOC "James MR &: Nature Genet, 8, 70-76, 1994 CLO,SEQ,EVO "McGuire EA &: Mol Cell Biol, 9, 2124-2132, 1989 LOC "Rabbitts TH &: CCG, 58, (HGM11), 1969, 1991 LOC "Redeker E &: CCG, 68, 222-225, 1995 LOC "Royer-Pokora B &: Oncogene, 10, 1353-1360, 1995 |
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KEY |
imm, onc, ont, neu, trc, hem |
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CLA |
coding, basic |
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LOC |
11 p15.3 |
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MIM |
MIM: 186921 |
|
SYN |
RBTN1 TCL6 |
