Gene: [11p153/LMO1] LIM domain only 1 (rhombotin 1); rhombotin 1 (rhombosine; T cell lymphoma associated breakpoint); T cell acute lymphoblastic leukemia 1 (rhombotin); T cell lymphoma 6 associated breakpoint; [RBTN1 TCL6 ]

FAG

Other six LMO sequences have been identified: GEM:11p13/LMO2, GEM:12p13/LMO3, GEM:11p151/LMO4, GEM:12q211/CSRP2(LMO5), GEM:0Xp112/LMO6, GEM:00.0/LMO7."

MOP

Rhombotin 1 (rhombosin) consists of 155 amino acid residues.

HET

Another T cell lymphoma marker identified in the same chromosome is retained yet in the MIM and GEM catalogues (GEM:11p13/TCL2), but was excluded from the HGM ones."

MUT

According to Greenberg-1989, T cell-associated translocation t(22;14)(p15;q11) in human affects the nucleic acid sequence in Chr 11p15, which was demonstrated to be transcribed in a model system on the developing rhombomers of murine cerebral trunk. But the relationship between rhombosine gene defects and T cell lymphoma is not confirmed definitely."

HIS

HGM9: gene symbol TCL6 HGM10: TAL1 HGM10.5: RBTN1 GDB LMO1."

REF

CLO,SEQ,EVO "Boehm T &: Oncogene, 6, 695-703, 1991a
CLO,SEQ,EVO "Boehm T &: PNAS, 88, 4367-4371, 1991b
CLO,SEQ,EVO "Boehm T &: EMBO J, 9, 857-868, 1990
LOC "Boehm T &: EMBO J, 7, 385-394, 1988a
LOC "Boehm T &: Oncogene, 3, 691-695, 1988b
LOC,CYG,EXP "Greenberg JM &: CCG, 51, (HGM10), 1008, 1989
LOC,LIN,MOL "Henry I &: CCG, 51, (HGM10), 1013, 1989a
LOC,LIN,MOL "Henry I &: Hum Genet, 81, 273-277, 1989b
LOC,LIN,MOL "Henry I &: PNAS, 86, 3247-3251, 1989c
LOC,LIN,MOL "Henry I &: Ann Genet, 31, 216-220, 1988
LOC,LIN,MOL "Henry I &: CCG, 46, (HGM9), 629, 1987
LOC "James MR &: Nature Genet, 8, 70-76, 1994
CLO,SEQ,EVO "McGuire EA &: Mol Cell Biol, 9, 2124-2132, 1989
LOC "Rabbitts TH &: CCG, 58, (HGM11), 1969, 1991
LOC "Redeker E &: CCG, 68, 222-225, 1995
LOC "Royer-Pokora B &: Oncogene, 10, 1353-1360, 1995

KEY

imm, onc, ont, neu, trc, hem

CLA

coding, basic

LOC

11 p15.3

MIM

MIM: 186921

SYN

RBTN1 TCL6

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