Gene: [11p155/INS] insulin; proinsulinemia;
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FAG |
The CCM92 and HGM catalogues included two INS-like genes (GEM:02^/INSL1 and GEM:11^/INSL2). The MIM catalogue usually does not register noncoding sequences; however, in this case it also included an INS-like marker with indicated localization in chr 6 (see GEM:06^/INSL)." |
|
HET |
A rare syndrome of combuned deficiency of three cytokines - insulin, somatomedin C (GEM:12q23/IGF1), and urogastrone (GEM:04q25/EGF) - was described (Werner-like syndrome; MIM:233805)." |
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REF |
POL,MOL,PAT "Amos &: Atherosclerosis, 79, 51-57, 1989 CLO,GEN,SEQ "Bell GI &: Nature, 284, 26-32, 1980 CLO,COD,SEQ "Bell GI &: Nature, 282, 525-527, 1979 MUT,MOL,MEB,PAT "Carroll RJ &: PNAS, 85, N23, 8943-8947, 1988 LOC,LIN,PRO,GEN "Chaganti &: Somat Cell Mol Genet, 1, N2, 197-202, 1985 MUT,MOL,MEB,PAT "Chan SJ &: PNAS, 84, N8, 2194-2197, 1987 REV,FUN,MEB,EXP,MOP "Derewenda &: Brit Med Bull, 45, N1, 4-18, 1989 MUT,MOL,MEB,PAT "Elbein &: Diabetes, 34, 821-824, 1985 MUT,MOL,MEB,PAT "Gabbay &: PNAS, 76, 2881-2885, 1979 PAT,PHE,FOG "Gabbay &: New Engl J Med, 294, 911-915, 1976 MUT,MOL,MEB,PAT "Gruppuso &: New Engl J Med, 311, 629-634, 1984 MUT,MOL,MEB,PAT "Haneda M &: Diabetes, 35, 115-118, 1986 MUT,MOL,MEB,PAT "Haneda M &: New Engl J Med, 310, 1288-1294, 1984 MUT,MOL,MEB,PAT "Haneda M &: PNAS, 80, N20, 6366-6370, 1983 LOC,CYG,PRO,GEN "Harper ME &: PNAS, 78, N7, 4458-4460, 1981 REV,FUN,MEB,EXP,MOP "Howell, Bird: Brit Med Bull, 45, N1, 19-36, 1989 LOC,CYG "Huerre &: CCG, 37, (HGM7), 495, 1984 LOC,LIN,MAP "Kazazian HH, Junien: CCG, 46, (HGM9), 188-212, 1987 MUT,MOL,MEB,PAT "Kwok SC &: Diabetes, 32, 872-875, 1983 MUT,MOL,MEB,PAT "Kwok SC &: BBRC, 98, 844-849, 1981 LOC,LIN,MAP "Lebo RV &: PNAS, 80, 4808-4812, 1983 LOC,CYG,PRO,COD "Lebo RV &: Hum Genet, 60, 10-15, 1982 LOC,LIN,MAP "Lebo RV &: AJHG, 33, 150A, 1981 RAT,GEN,SEQ,EVO "Lomedico &: Cell, 18, 545-558, 1979 POL,MOL,PAT "Mandrup-Poulsen &: Lancet, 1, 250-254, 1984 LOC,LIN,MAP "Meyers DA &: AJHG, 39, 539-541, 1986 LOC,MOL,MUT,CHR "Morris &: Brit J Haematol, 71, 481-486, 1989 MUT,MOL,MEB,PAT "Nanjo &: J Clin Invest, 77, 514-519, 1986 LOC,LIN,MAP "O'Malley KL, Rotwein: NAR, 16, 4437-4446, 1988 LOC,CYG,PRO,COD "Owerbach D &: Nature, 286, (3 Jul), 82-84, 1980 MUT,MOL,MEB,PAT "Robbins &: J Clin Invest, 73, 714-719, 1984a REV,FUN,MEB,EXP,MOP "Robbins &: New Engl J Med, 310, 1165-1175, 1984b MUT,MOL,MEB,PAT "Robbins &: Nature, 291, 679-681, 1981 POL,MOL,PAT "Rotwein P &: AJHG, 39, 291-299, 1986 POL,MOL,PAT "Rotwein P &: Science, 213, 1117-1120, 1981 MUT,MOL,MEB,PAT "Sacura H &: J Clin Invest, 78, N6, 1666-1672, 1986 MUT,MOL,MEB,PAT "Schwartz &: PNAS, 84, N18, 6408-6411, 1987 MUT,MOL,MEB,PAT "Seino &: Diabetes, 34, 1-7, 1985 REV,EXP,ENG,TER "Selden &: New Engl J Med, 317, 1067-1076, 1987 MUT,MOL,MEB,PAT "Shibasaki Y &: J Clin Invest, 76, N1, 378-380, 1985 MUT,MOL,MEB,PAT "Shoelson S &: Nature, 302, 540-543, 1983a MUT,MOL,MEB,PAT "Shoelson S &: PNAS, 80, N24, 7390-7394, 1983b REV,GEN,FUN,EVO "Steiner &: Annu Rev Genet, 19, 463-484, 1985 CLO,COD,SEQ "Sures &: Science, 208, 57-59, 1980 MUT,MOL,MEB,PAT "Tager &: Nature, 281, 122-125, 1979 GEN,TRC,EXP "Takeda &: FEBS Lett, 247, (Apr), N1, 41-45, 1989 MUT,MOL,MEB,PAT "Ullrich A &: Science, 209, N4456, 612-615, 1980 REV,PAT,MUT,MEB "Vinik, Bell: Horm Metab Res, 20, 1-10, 1988 MUT,MOL,MEB,PAT "Vinik &: J Clin Endocrinol Metab, 62, 645-652, 1986 PAG "Williams LG &: Hum Genet, 71, 227-230, 1985 |
|
KEY |
horm, cyk, carb |
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CLA |
coding, basic |
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LOC |
11 p15.5 |
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MIM |
MIM: 176730 |
