Gene: [11p155/TH] tyrosine hydroxylase;

FUN

 [1] The enzyme plays an important role in the the physiology of adrenergic neurons. It catalyzes the rate-limiting step in catecholamine biosynthesis.
[2] Systematic name: L-tyrosine,tetrahydropteridine:oxygen oxidoreductase. Catalyzes reaction: L-tyrosine + tetrahydropteridine + O(2) = = 3,4-dihydroxy-L-phenylalanine + dihydropteridine + H(2)O."

REF

 GEN,LOC,MOL,EVO "Craig &: CCG, 42, 29-32, 1986
PRO,LOC,LIN,MOL "Craig &: CCG, 40, (HGM8), 610, 1985
EXP,FUN "Dumas &: J Neurosci Res, 25, N4, 569-575, 1990
CLO,SEQ,EXP "Grima B &: Nature, 326, 707-711, 1987
CLO,SEQ,EXP "Grima B &: PNAS, 82, 617-621, 1985
PRO,LOC,LIN,MOL "Jeanpierre &: CCG, 40, (HGM8), 661, 1985
PRO,LOC,LIN,MOL "O'Malley KL, Rotwein: NAR, 16, 4437-4446, 1988
PRO,LOC,LIN,MOL "Xue &: CCG, 46, (HGM9), 721-722, 1987

KEY

 neu, aac

CLA

 coding, basic

LOC

 11 p15.5

MIM

 MIM: 191290

EZN

 ENZYME: 1.14.16.2

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