Gene: [11q13/CFL1] cofilin 1 (non-muscle); [CFL ]
|
COM |
The CFL1 gene was mapped to chromosome 11q13 by fluorescence in situ hybridization (Gillett-1996)." |
|
FUN |
Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus." |
|
FAG |
[1] A gene coding for another cofilin has been mapped to chr 14: GEM:14^/CFL2.
[2] About actin genes see in: FAM:ACT/00.0." |
|
LIK |
GEM:00.0/CFLL1; GEM:00.0/CFLL2; GEM:00.0/CFLL3; GEM:00.0/CFLL4. |
|
REF |
MAP "Courseaux A &: Genomics, 37, N3, 354-365, 1996 CLO,SEQ,STR,LOC "Gillett GT &: Ann Hum Genet, 60, 201-211, 1996 CLO,SEQ "Ogawa K &: NAR, 18, 7169, 1990 |
|
KEY |
cysk |
|
CLA |
coding, basic |
|
LOC |
11 q13 |
|
MIM |
MIM: 601442 |
|
SYN |
CFL |
