Gene: [12p13/GAPD] glyceraldehyde-3-phosphate dehydrogenase;

FUN

[1] The holoenzyme is presumed to be a homotetramer. It catalyzes the energetically important stage of glycolysis - oxidative phosphorylation.
[2] Systematic name: D-glyceraldehyde 3-phosphate:NAD+ oxidoreductase (phosphorylating). Catalyzes reaction: D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH."

FAG

Benham-1989 confirmed the presence of a single expressed locus for this major glycolytic enzyme on 12p13. One proved pseudogene is mapped to Chr Xp11 (GEM:0Xp11/GAPDP1). Over 15 GAPD-like sequences have been revealed, they being dispersed among various chromosomes, including Chr X: GEM:01^/GAPDL1; GEM:0X^/GAPDL2; GEM:02q/GAPDL3; GEM:04^/GAPDL4; GEM:06^/GAPDL5; GEM:15^/GAPDL6; GEM:08^/GAPDL7; GEM:06^/GAPDL8; GEM:01^/GAPDL9; GEM:0X^/GAPDL10; GEM:18^/GAPDL11; GEM:0Xq/GAPDL12; GEM:07^/GAPDL13; GEM:13q12/GAPDL14; GEM:11^/GAPDL15; GEM:05q3/GAPDL16."

REF

LOC,FAG "Benham FJ, Povey S: Genomics, 5, 209-214, 1989
LOC,FAG "Benham FJ, Povey S: CCG, 46, (HGM9), 579, 1987
MOP,ASS "Burke JR &: Nature Med, 2, 347-350, 1996
PEP,SEQ,MOP "Kovalyov LI &: Electrophoresis, 16, 1160-1169, 1995
SEQ "Meyer-Siegler K &: PNAS, 88, 8460-8464, 1991
LOC,FAG "Pattrachini P &: CCG, 46, (HGM9), 675, 1987
EVO,FAG "Piechaczyk M &: Nature, 312, 469-471, 1984
LOC,CYG "Rivas F &: Ann Genet, 28, 189-192, 1985
COD,SEQ,FAG,CAG "Tso JY &: NAR, 13, 2485-2505, 1985

SWI

SWISSPROT: P00354; G3P2 P04406

KEY

glyc

CLA

coding, basic

LOC

12 p13.31-.1

MIM

MIM: 138400

EZN

ENZYME: 1.2.1.12

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