Gene: [12p1/A2M] alpha-2-macroglobulin;
FAG | According to Marynen-1989, A2M gene is located within a complex locus arranged as a tandem cluster of several related genes, including an A2M pseudogene (GEM:12p1/A2MP) and PZP gene (gestation protein; GEM:12p1/PZP)." |
FUN | The protein is an inhibitor of four basic classes of serum proteinases: serine, thiol (cysteine), and acid proteinases, as well as metalloproteinases." |
REF | PRO,LOC,POL,REL "Bell GI &: CCG, 40, 579-580, 1985a PRO,LOC,POL,REL "Bell GI &: Somat Cell Mol Genet, 11, 285-289, 1985b LOC,GEN,SEQ,EXP "Devriendt K &: Gene, 81, 325-334, 1989 LOC "Fukushima Y &: CCG, 48, 58-59, 1988 PRO,LOC,POL,REL,SEQ "Kan CC &: PNAS, 82, 2282-2286, 1985 LOC,MOL,GEN,EXP,PRO,POL,REL "Marynen P &: CCG, 51, (HGM10), 1040, 1989 PRO,LOC,POL,REL "Marynen P &: NAR, 13, 8287, 1985 PRO,LOC,POL,REL "Matthijs G &: BBRC, 202, 65-72, 1994 PRO,LOC,POL,REL "Poller W &: NAR, 19, N1, 198, 1991 PRO,LOC,POL,REL "Poller W &: Hum Genet, 83, 93-96, 1989 PRO,LOC,POL,REL "Poloni ES &: Ann Hum Genet, 59, 43-61, 1995 |
SWI | SWISSPROT: P01023 |
KEY | hem, pep, serp |
CLA | coding, basic |
LOC | 12 p13-12.3 |
MIM | MIM: 103950 |
