Gene: [12q22/LTA4H] leukotriene A4 hydrolase;

MOP

MM about 69.15kD (610 amino acids); the mature transcript is 2.25 kb; the cDNA contains a short 3'-untranslated AT-rich (72%) region."

FUN

The enzyme hydrolyzes an epoxide moiety of LTA4 to form LTB4. Also has some peptidase activity."

TIS

The leukotriene A4 hydrolase is a cytoplasmic enzymes occurring in many organs and tissues."

REF

REV,FUN "Ford-Hutchinson, Letts: Hypertension, 8, (Ii.), 44-49, 1986
PRO,SEQ,MOP "Funk CD &: PNAS, 84, N19, 6677-6681, 1987
CLO,SEQ,GEN,LOC "Mancini JA, Evans JF: Eur J Biochem, 231, 65-71, 1995
PRO,SEQ,MOP "Minami M &: JBC, 262, 13873-13876, 1987
FUN "Radmark O &: Methods Enzymol, 187, 486-491, 1990
REV,FUN "Shimizu &: Int J Biochem, 20, N7, 661-666, 1988

SWI

 SWISSPROT: P09960

KEY

hem, card, imm, mfd

CLA

coding, basic

LOC

12 q22

MIM

 MIM: 151570

EZN

 ENZYME: 3.3.2.6