Gene: [12q2/LUM] lumican (keratan sulfate proteoglycan); [LDC ]
SUM | Lumican, a member of the small interstitial proteoglycan gene (SIPG) family, is a keratan sulfate proteoglycan present in large quantities in the corneal stroma and in interstitial collagenous matrices of the heart, aorta, skeletal muscle, skin, and intervertebral discs (Chakravarti-1995b). Other SIPG members are decorin (GEM:12q23/DCN), biglycan (GEM:0Xq28/BGN), and fibromodulin (GEM:01q32/FMOD). Like decorin, lumican interacts with collagen and limits growth of fibrils in diameter. In the cornea, lumican not only interacts with collagen molecules to limit fibril growth, but by virtue of its keratan sulfate-containing glycosaminoglycan side chains LDC plays a critical role in the regular spacing of fibrils and acquisition of corneal transparency. The primary structure of lumican, derived from cDNA sequencing of chicken, bovine, and human clones, shows all the characteristic features of the SIPG family, namely, 4 and 2 cysteines in the N- and C-terminal globular domains, I and III, and a central, cysteine-free domain II, with 9 beta sheet-forming leucine motifs." |
GEN | The gene length: 7.5 kb; exons: 3 (Grover-1995). |
TIS | Lumican is present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In adult cartilage, lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan (Grover-1995)." |
REF | LOC,COD,SEQ
"Chakravarti S &: Genomics, 27, 481-488, 1995a EVO,LOC,MOU "Chakravarti S, Magnuson T: Mammal Genome, 6, 367-368, 1995b LOC,COD,GEN,SEQ,EXP,TIS "Grover J &: JBC, 270, 21942-21949, 1995 |
SWI | SWISSPROT: P51884 |
KEY | exce |
CLA | coding, basic |
LOC | 12 q21.3-22 |
MIM | MIM: 600616 |
SYN | LDC |
