Gene: [12q/MYPT1] myosin phosphatase target subunit 1 (myosin-binding); [MBS ]

COM

Fluorescence in situ hybridization placed the MYPT1 gene on 12q15-q21.2 (Takahashi-1997)."

FUN

Myosin phosphatase regulates the interaction of actin (FAM:ACT/00.0) and myosin (see GEM:17p131/MYH1) downstream of the guanosine triphosphatase Rho (Kimura-1996)."

FAG

On the gene for myosin-binding protein C (slow-type) see GEM:12^/MYBPC1.

REF

COD,EXP,FUN "Kimura K &: Science, 273, N5272, 245-248, 1996
COD,SEQ,LOC "Takahashi N &: Genomics, 44, 150-152, 1997

KEY

myo

CLA

coding, basic

LOC

12 q15-q21.2

MIM

MIM: 602021

SYN

MBS