Gene: [13q34/SOX1] SRY (sex determining region Y)-related HMG-box gene 1;
COM | The SRY (GEM:0Yp113/SRY) and SOX proteins share a DNA-binding domain known as the HMG box, defined by a 79-amino acid region. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 (GEM:03q2/SOX2), and SOX3 (GEM:0Xq2/SOX3) show the closest homology to SRY. They share maximum homology within the HMG domain (Collignon-1996)." |
REL | GEM:03q2/SOX2; GEM:0Xq2/SOX3; GEM:06p22/SOX4; GEM:12p121/SOX5; GEM:08q211/SOX5P; GEM:00.0/SOX6; GEM:17q2/SOX9; GEM:22q1/SOX10; GEM:02p25/SOX11; GEM:00.0/SOX12; GEM:20q1/SOX18; GEM:17p13/SOX20; GEM:20p13/SOX22." |
REF | EVO,EAG "Collignon J
&: Development, 122, 509-520, 1996 COD,EVO,LOC "Malas S &: Mammal Genome, 8, N11, 866-868, 1997 |
SWI | SWISSPROT: O00570 |
KEY | chr |
CLA | coding, basic |
LOC | 13 q34 |
MIM | MIM: 602148 |
