Gene: [14q/PFGS] phosphoribosylformylglycinamidine synthetase; adenine(-) b-auxotroph;

COM

The gene is not registered in the GDB.

FUN

[1] The 4th enzyme in purine biosynthesis de novo.
[2] Systematic name: 5'-phosphoribosylformylglycinamide:L-glutamine amidoligase (ADP-forming).
[3] Catalyzes reaction: ATP + 5'-phosphoribosylformylglycinamide + L-glutamine + H(2)O = ADP + + orthophosphate + 5'-phosphoribosylformylglycinamidine + L-glutamate."

FAG

See GEM:21q221/GART and GEM:14q24/MTHFD.

REF

LOC "Jones C &: Somat Cell Genet, 7, 399-409, 1981
LOC "Kao &: CCG, 37, (HGM7), 504-505, 1984

KEY

nucm

CLA

coding, basic

LOC

14 q22-t

MIM

MIM: 172460?

EZN

ENZYME: 6.3.5.3