Gene: [14q/PFGS] phosphoribosylformylglycinamidine synthetase; adenine(-) b-auxotroph;
|
COM |
The gene is not registered in the GDB. |
|
FUN |
[1] The 4th enzyme in purine biosynthesis de novo.
[2] Systematic name: 5'-phosphoribosylformylglycinamide:L-glutamine amidoligase (ADP-forming). [3] Catalyzes reaction: ATP + 5'-phosphoribosylformylglycinamide + L-glutamine + H(2)O = ADP + + orthophosphate + 5'-phosphoribosylformylglycinamidine + L-glutamate." |
|
FAG |
See GEM:21q221/GART and GEM:14q24/MTHFD. |
|
REF |
LOC "Jones C &: Somat Cell Genet, 7, 399-409, 1981 LOC "Kao &: CCG, 37, (HGM7), 504-505, 1984 |
|
KEY |
nucm |
|
CLA |
coding, basic |
|
LOC |
14 q22-t |
|
MIM |
MIM: 172460? |
|
EZN |
ENZYME: 6.3.5.3 |
