Gene: [15q15/GRP58] glucose regulated protein, 58kD; thiol-dependent reductase? GRP58; protein disulfide isomerase (EC:5.3.4.1);

COM

The GRP58 gene was mapped to Chr 15q15 using fluorescence in situ hybridization (Koivunen-1997)."

GEN

The gene length: 18 kb. Exons: 13 (Koivunen-1997). The GRP58 sequence has 2 thioredoxin-like domains."

FUN

[1] Hirano et al. expressed human GRP58 and found that the protein had a thiol-dependent reductase activity (Hirano-1995).
[2] The GRP58 is suggested to function in combination with calnexin (GEM:05q35/CANX) and calreticulin (GEM:19p132/CALR) as a molecular chaperone of glycoprotein biosynthesis (Oliver-1997)."

PSG

GEM:01q21/GRP58P.

REF

CLO,SEQ,GEN "Charnock-Jones D &: Int J Biochem Cell Biol, 28, 811-819, 1996
COD,SEQ,EXP,FUN "Hirano N &: Eur J Biochem, 234, 336-342, 1995
GEN,SEQ,EVO,LOC,FAG "Koivunen P &: Genomics, 42, 397-404, 1997
CLO,SEQ "Koivunen P &: Biochem J, 316, 599-605, 1996
COD,SEQ,EXP,FUN "Oliver JD &: Science, 275, 86-88, 1997

SWI

SWISSPROT: P30101

KEY

carb

CLA

coding, basic

LOC

15 q15

MIM

MIM: 602046

EZN

ENZYME: 5.3.4.1