Gene: [15q15/GRP58] glucose regulated protein, 58kD; thiol-dependent reductase? GRP58; protein disulfide isomerase (EC:5.3.4.1);
COM | The GRP58 gene was mapped to Chr 15q15 using fluorescence in situ hybridization (Koivunen-1997)." |
GEN | The gene length: 18 kb. Exons: 13 (Koivunen-1997). The GRP58 sequence has 2 thioredoxin-like domains." |
FUN | [1] Hirano
et al. expressed human GRP58 and found that the protein had a
thiol-dependent reductase activity (Hirano-1995). [2] The GRP58 is suggested to function in combination with calnexin (GEM:05q35/CANX) and calreticulin (GEM:19p132/CALR) as a molecular chaperone of glycoprotein biosynthesis (Oliver-1997)." |
PSG | GEM:01q21/GRP58P. |
REF | CLO,SEQ,GEN
"Charnock-Jones D &: Int J Biochem Cell Biol, 28, 811-819, 1996 COD,SEQ,EXP,FUN "Hirano N &: Eur J Biochem, 234, 336-342, 1995 GEN,SEQ,EVO,LOC,FAG "Koivunen P &: Genomics, 42, 397-404, 1997 CLO,SEQ "Koivunen P &: Biochem J, 316, 599-605, 1996 COD,SEQ,EXP,FUN "Oliver JD &: Science, 275, 86-88, 1997 |
SWI | SWISSPROT: P30101 |
KEY | carb |
CLA | coding, basic |
LOC | 15 q15 |
MIM | MIM: 602046 |
EZN | ENZYME: 5.3.4.1 |
