Gene: [15q2/IDH2] isocitrate dehydrogenase 1 (NADP+), mitochondrial;
HIS | Distinctions existed in literature on EC isoforms of isocitrate dehydrogenase. Enzyme Nomenclature (1979) indicated two isocitrate dehydrogenases - NAD-dependent (EC:1.1.1.41) and NADP-dependent (EC:1.1.1.42) ones; HGM indicated the code EC:1.1.1.42 for both enzymes; Grzeschik-1976 assigned the code EC:1.1.1.41 to the isoform mapped in chr 15; Shimizu-1977 referred to the isoform mapped in chr 15q as NADP-dependent one (i.e. EC:1.1.1.42). However, Narahara-1985 indicated the code EC:1.1.1.42 for IDH1 isoform, which they mapped to chr 2q." |
FUN | The catalyzed reaction: isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH." |
FAG | The cytoplasmic (soluble) isoform, isocitrate dehydrogenase 1, is mapped to Chr 2q (GEM:02q333/IDH1)." |
REF | LOC,CYG "Bruns GA &:
CCG, 17, 200-211, 1976 LOC,CYG "Champion &: CCG, 22, 498-502, 1978 LOC,CYG "Grzeschik Kh: Hum Genet, 34, 23-28, 1976 LOC,CYG "Shimizu N &: Somat Cell Genet, 3, 47-60, 1977 |
SWI | SWISSPROT: P48735 |
KEY | mito, cytr |
CLA | coding, basic |
LOC | 15 q2 |
MIM | MIM: 147650 |
EZN | ENZYME: 1.1.1.42 |
