Gene: [15q2/PKM] pyruvate kinase, muscle (M1; M2; PK2); pyruvate kinase, kidney (PK3; MIM:179040); thyroid hormone binding protein, cytosolic (p58; MIM:188555);

COM

[1] By in situ hybridization, the THBP1 gene was mapped to 15q24-q25 (Popescu-1990).
[2] The sequence of the cDNA for p58/THBP1 indicated that it is homologous to a subunit of pyruvate kinase, subtype M2."

FAG

[1] Two different genes - PKM and PKL (liver pyruvate kinase, GEM:01q21/PKL) are supposed to code for four pyruvate kinase isoforms (M1, M2, L, and R) via the alternative splicing.
[2] The liver pyruvate kinase gene is mapped in chr 1q (GEM:01q21/PKL). Deficiency of its product is thought to cause hemolytic anemia (MIM:266200; PK1). MIM indicates also (as a secondary marker, without description) PK2 (MIM:179040), which represents one of two forms encoded by PKM gene."

REF

LOC,LIN,CYG "Chern &: Somat Cell Genet, 3, 553-560, 1977
LOC,LIN,CYG "Chern, Croce: CCG, 15, 299-305, 1975
LOC,LIN,CYG "Junien C &: Hum Genet, 54, 191-196, 1980
PEP,SEQ,EVO,MOP "Kahn &: BBA, 523, 58-74, 1978
COD,SEQ "Kitagawa S &: JBC, 262, 3903-3908, 1987
PEP,SEQ,EVO,MOP "Levine &: Nature, 271, 626-630, 1978
PEP,SEQ,EVO,MOP "Nakashima &: J Lab Clin Med, 90, 1012-1020, 1977
LOC "Popescu NC, Cheng SY: Somat Cell Mol Genet, 16, 593-598, 1990
LOC,LIN,CYG "Shows TB: AJHG, 24, 13A, 1972
EXP,PRO,GEN,MOL "Tsutsumi H &: Genomics, 2, N1, 86-89, 1988
LOC,LIN,CYG "van Heyningen V &: Ann Hum Genet, 38, 295-303, 1975
LOC,LIN,CYG "Westerveld A &: CCG, 14, 453-454, 1975

SWI

SWISSPROT: P14618; KPY2 P14786

KEY

glyc, cytr, horm

CLA

coding, basic

LOC

15 q24-25

MIM

MIM: 179050

EZN

ENZYME: 2.7.1.40

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