Gene: [16p133/AXIN1] axin;

FUN

Axin is a negative regulator of embryonic axis formation in vertebrates, which acts through a Wnt signal transduction pathway involving the serine/threonine kinase GSK-3 (see GEM:00.0/GSK3A) and beta-catenin (GEM:03p213/CTNNB1). Axin has been shown to have distinct binding sites for GSK-3 and beta-catenin and to promote the phosphorylation of beta-catenin and its consequent degradation. This provides an explanation for the ability of Axin to inhibit signaling through beta-catenin. In addition, a more N-terminal region of Axin binds to adenomatous polyposis coli (GEM:05q2/APC), a tumor suppressor protein that also regulates levels of beta-catenin (Hsu-1999)."

REL

GEM:00.0/AXIN2.

REF

COD,EVO "Hsu W &: JBC, 274, N6, 3439-3445, 1999
COD,EVO,LOC "Zeng L &: Cell, 90, 181-192, 1997

KEY

ont, onc, sign

CLA

coding, basic

LOC

16 p13.3

MIM

?