Gene: [16p13/PPL] periplakin;
|
COM |
The PPL gene was mapped to the interval between D16S510 and D16S509 by radiation hybrid mapping, corresponding to chromosomal band 16p13 (Aho-1998)." |
|
FAG |
The intermediate filament cytoskeleton of keratinocytes, composed of keratins that are expressed in specific expression pairs according to tissue and differentiation state, are interconnected through transmembrane protein complexes called desmosomes and connect with the basement membrane via hemidesmosomes. The proteins thought to make contact with the intermediate filaments of keratinocytes belong to a family of proteins known as plakins, of which desmoplakin (GEM:06p2/DSP) and envoplakin (GEM 17q25/EVPL) are members. The proteins in this family have a similar overall domain structure that includes an amino-terminal globular domain, a central coiled-coil rod domain, and a carboxy-terminal tail with characteristic repeat sequences (Aho-1998)." |
|
REF |
COD,SEQ,LOC,EXP,EAG "Aho S &: Genomics, 48, 242-247, 1998 |
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KEY |
cysk |
|
CLA |
coding, basic |
|
LOC |
16 p13 |
|
MIM |
MIM: 602871 |
