Gene: [17q1/TRAF4] TNF receptor-associated factor 4 (malignant 62); cysteine-rich domain associated with RING and TRAF domains (CART1); [MLN62 CART1 ]
|
COM |
The TRAF4 gene was mapped to Chr 17q11-12 by radioisotopic in situ hybridization (Tomasetto-1995)." |
|
FUN |
The CART1 protein appears to be involved in TNF-related cytokine signal transduction in breast carcinoma." |
|
GEN |
The gene length: 5.5 kb (approximately); exons: 7 (Regnier-1995). |
|
MOP |
TRAF4 encodes a predicted 470-amino acid protein that has an unusual RING finger motif at the N terminus, a cysteine-rich domain, called a CART motif, more centrally located, and a TRAF domain at the C terminus (Regnier-1995)." |
|
REF |
COD,SEQ,DOM,EVO "Regnier CH &: JBC, 270, N43, 25715-25721, 1995 LOC,COD,EXP "Tomasetto C &: Genomics, 28, N3, 367-376, 1995 |
|
KEY |
onc |
|
CLA |
coding, basic |
|
LOC |
17 q11-12 |
|
MIM |
MIM: 602464 |
|
SYN |
MLN62 CART1 |
