Gene: [17q213/NME1] nucleoside diphosphate kinase A; metastasis inhibition factor NM23-H1; non-metastatic cells 1, protein expressed in (NM23A); neuroblastoma;
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COM |
The NME1 gene has been mapped to Chr 17q22 by in situ hybridization (Varesco-1992). Backer-1993 assigned the metastasis inhibition factor NM23-H1 and MN23-H2 (GEM:17q213/NME2) genes to Chr 17q21.3." |
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MUT |
Chang-1994 identified a ser120-to-gly substitution in the NM23 gene in 6 of 28 advanced neuroblastomas but in none of 22 limited-stage neuroblastomas. The mutation was inherited in 1 case and was a somatically acquired mutation in a second case. It was not found in 36 normal individuals and was not found in 26 breast carcinomas in 17 acute leukemias, excluding the possibility that it represents a common polymorphism." |
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REL |
GEM:17q213/NME2; GEM:16q13/NME3; GEM:16p133/NME4; GEM:05q/NME5. |
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REF |
LOC "Backer JM &: Oncogene, 8, N2, 497-502, 1993 PAT,MUT "Chang CL &: Nature, 370, 335-336, 1994 GEN,SEQ "Dooley S &: Hum Genet, 93, 63-66, 1994 PRO,LOC "Eddy RL &: CCG, 58, (HGM11), 2005, 1991 PEP,MOP "Gilles A-M &: JBC, 266, 8784-8789, 1991 MUT "Leone A &: Cancer Res, 51, 2490-2493, 1991 CLO "Steeg PS &: J Nat Cancer Inst, 80, 200-204, 1988 PRO,LOC,POL "Varesco L &: Genes Chromosom Cancer, 4, 84-88, 1992 |
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KEY |
onc, nucm |
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CLA |
coding, basic |
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LOC |
17 q21.3 |
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MIM |
MIM: 156490 |
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EZN |
ENZYME: 2.7.4.6 |
