Gene: [17q23/DCP1] dipeptidyl carboxypeptidase 1 (angiotensin I converting enzyme); peptidyl dipeptidase A (peptidase P; angiotensin I-converting enzyme);
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FUN |
[1] Dipeptidyl carboxypeptidase I (DPKP-I) is one of the components of
renin-angiotensin system (RAS), which is of critical importance in the
maintenance of vascular homeostasis. This system includes
<1> angiotensinogen (GEM:01q4/AGT) and products
of its proteolysis,
angiotensin I (A-I) and angiotensin II (A-II);
<2> renin (angiotensinogenase; GEM:01q32/REN),
which splits a
decapeptide from the C-terminus of angiotensinogen to form A-I;
<3> DPKP-I, which splits a carboxydepeptide from A-I to form A-II;
<4> receptors for A-II, which genes are not yet specified.
[2] In systemic functional terms, cerebral, cardiac/renal (circulatory), and local tissue (intrcellular) RASs are distinguished. Molecular differences between tissue isoforms of DPKP-I have been found. Thus, a high-molecular isoform (160-170 kD; cDNA cloned: Soubrier-1988) primarily isolated from lung tissue and relatively low-molecular one (100-110 kD; cDNA cloned: Ehlers-1989), which is testicle-specific and androgen-dependent, were found. Both isoforms are encoded by the same DCP gene and the same pre-mRNA, being synthesized in different ways through alternative splicing, the testicle isoform (almost identical to the C-terminal part of lung isoform) appearing to be 30% shorter and to differ also in the N-terminal signal peptide (the first 36 amino acids)." |
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REF |
SEQ,EXP,MOP "Ehlers MR &: PNAS, 86, N20, 7741-7745, 1989a REV,FUN,MEB "Ehlers MR, Riordan: Biochemistry, 28, N13, 5311-5318, 1989b REV,FUN,MEB "Jin &: Am J Med, 84, (Suppl 3A, 11 Mar), 28-36, 1988 LOC,PRO "Mattei &: CCG, 51, (HGM10), 1041, 1989 SEQ,EXP,MOP "Soubrier F &: PNAS, 85, N24, 9386-9390, 1988 |
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KEY |
pep, horm |
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CLA |
coding, basic |
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LOC |
17 q23 |
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MIM |
MIM: 106180 |
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EZN |
ENZYME: 3.4.15.1 |
