Gene: [17q25/P4HB] procollagen-proline, 2-oxoglutarate 4-dioxygenase (EC:1.14.11.2), beta; prolyl 4-hydroxylase (EC:1.14.11.2), beta; protein disulfide isomerase (EC:5.3.4.1); glutathione-insulin transhydrogenase (EC:1.8.4.2); thyroid hormone binding protein p55;
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FUN |
The beta monomer (60kD) possesses activities of disulfide isomerase (EC:5.3.4.1), or glutathion:proteindisulfide oxidoreductase (EC:1.8.4.2); being associated with the 64kD alpha monomer (see GEM:10q2/P4HA), the both monomers form tetramer (2A+2B) possessing the proline-4-hydroxilase activity (EC:1.14.11.2) that catalyses 4-hydroxylation of proline residues in preprocollagen." |
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FAG |
About pancreas protein disulfide isomerase see GEM:16p133/PDIP. |
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REL |
GEM:00.0/P4HBR. |
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REF |
CLO,SEQ,EXP "Cheng S-Y &: JBC, 262, 11221-11227, 1987 FUN,PEP "Cheng S-Y &: PNAS, 83, N4, 947-951, 1986 FUN,PEP "Edman JC &: Nature, 317, 267-270, 1985 FUN,PEP "Freedman &: Biochem Soc Trans, 12, 929-932, 1984 FUN,PEP "Hasumura &: Biochemistry, 25, 7881-7888, 1986 REV,FUN,MEB "Kivirikko &: FASEB J, 3, (Mar), 1609-1617, 1989 FUN,PEP "Kivirikko, Myllyla: Ann NY Acad Sci, 460, 187-201, 1985 FUN,PEP "Kivirikko, Myllyla: Methods Enzymol, 82, 245-304, 1982 FUN,PEP "Koivu J &: JBC, 262, 6159-6164, 1987a FUN,PEP "Koivu J &: JBC, 262, 6447-6449, 1987b FUN,PEP "Koivu J, Myllyla: Biochemistry, 25, 5982-5986, 1986 CLO,SEQ,EXP "Morris JI, Varandani: BBA, 949, 169-180, 1988 LOC "Pajunen L &: CCG, 56, 165-168, 1991 LOC "Pajunen L &: CCG, 47, 37-41, 1988 LOC "Pajunen L &: CCG, 46, (HGM9), 674, 1987 CLO,SEQ,EXP "Pihlajaniemi T &: EMBO J, 6, 643-649, 1987 LOC "Popescu NC &: AJHG, 42, 560-564, 1988 FAG "Shoulders CC &: Hum Mol Genet, 2, 2109-2116, 1993 CLO,SEQ,LOC "Tasanen K &: JBC, 267, N16, 11513-11519, 1992 FUN,PEP "Thompson CC &: Science, 237, 1610-1614, 1987 FUN,PEP "Willigham &: J Histochem Cytochem, 35, 1043-1046, 1987 |
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KEY |
exce, horm |
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CLA |
coding, basic |
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LOC |
17 q25 |
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MIM |
MIM: 176790 |
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EZN |
ENZYME: 1.8.4.2? |
