Gene: [18q213/GRP] gastrin-releasing peptide;

FUN

Gastrin releasing peptide is a polypeptide consisting of 27 amino acid residues, which is of widespread occurrence in neuroendocrine cells of mammalian nervous system, respiratory tract, and digestive tract."

EXP

GRP1 and GRP2 peptides are produced by alternative splicing.

EVO

The protein product is phylogenetically homologous to the amphibian tetradecapeptide bombesin."

REF

LOC,MOL "Lebacq-Verheyden AM &: Somat Cell Mol Genet, 13, N1, 81-86, 1987
FUN,EVO "McDonald &: BBRC, 90, 227-233, 1979
LOC,MOL "Naylor SL &: Somat Cell Mol Genet, 13, N1, 87-91, 1987
LOC,MOL "Naylor SL &: CCG, 40, (HGM8), 711, 1985
EXP,MOP "Sausville EA &: JBC, 261, 2451-2457, 1986
EXP,SEQ,MOP "Spindel ER &: PNAS, 83, N1, 19-23, 1986
PRO,SEQ "Spindel ER &: PNAS, 81, 5699-5703, 1984

SWI

SWISSPROT: P07491; GRP2 P07492

KEY

horm, git, neu

CLA

coding, basic

LOC

18 q21.32-.33

MIM

MIM: 137260