Gene: [18q2/TS] thymidylate synthetase (methylenetetrahydrofolate methyltransferase);
FUN | [1]
Thymidylate synthetase catalyzes the only pathway for the synthesis of dTMP
de novo. [2] Systematic name: 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase. [3] Catalyzes reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." |
REF | PRO,GEN,EXP,ENG "Ayusawa &: JBC, 259, N23, 14361-14364,
1984 LOC "Hori T &: CCG, 40, (HGM8), 654-655, 1985a LOC "Hori T &: Somat Cell Mol Genet, 11, N3, 277-283, 1985b GEN,SEQ,EXP "Kaneda &: Annu Rep Inst Genet, 39, (Japan), 28-29, 1988a GEN,SEQ,EXP "Kaneda &: Annu Rep Inst Genet, 39, (Japan), 29, 1988b LOC "Ledbetter &: AJHG, 36, 203S, 1984 FUN "Nussbaum RL &: AJHG, 37, 1192-1205, 1985 PRO,GEN,EXP,ENG "Takeishi K &: J Biochem, 106, 575-583, 1989 PRO,SEQ,EXP,MOP "Takeishi K &: NAR, 13, 2035-2043, 1985 PRO,GEN,EXP,ENG "Takeishi K &: J Biochem, 95, 1477-1483, 1984 |
SWI | SWISSPROT: P04818 |
KEY | repr |
CLA | coding, basic |
LOC | 18 q21.31-t |
MIM | MIM: 188350 |
EZN | ENZYME: 2.1.1.45 |
